Concise synthesis of developed pleurotin

A photoredox radical epimerization generates the tetracyclic skeleton of pleurotin. Credit: The Sorensen Lab From the perspective of chemists, pleurotin is an intriguing molecule. There is strong evidence of untapped therapeutic properties as a tumor inhibitor and antibiotic. It has a fascinating complex structure (six rings! eight stereocenters!). And it has been difficult to synthesize … Read more

New technique could accelerate DNA synthesis

Credit: Pixabay/CC0 Public Domain pH—the concentration of protons in a watery solution—indicates how acidic the solution is. It regulates a broad range of natural and engineered chemical processes, including the synthesis of designed DNA sequences for applications in biotechnology. Changing the pH uniformly across an entire water-based solution is a standard practice in chemistry. But … Read more

Synthesis of two-dimensional holey graphyne

Holey graphene produced using a conventional top-down approach. The size and distribution of holes generated are uneven. Credit: Institute for Basic Science Diamond and graphite are two naturally occurring carbon allotropes that have known about for thousands of years. They are elemental carbons that are arranged in a manner so that they consist of sp3 … Read more

Automated synthesis allows for discovery of unexpected charge transport behavior in organic molecules

Automated synthesis platform in the Molecule Marker Lab. Credit: University of Illinois Urbana-Champaign A cross-disciplinary University of Illinois at Urbana-Champaign (UIUC) team has demonstrated a major breakthrough in using automated synthesis to discover new molecules for organic electronics applications. The technology that enabled the discovery relies on an automated platform for rapid molecular synthesis at … Read more