Structure of wheat immune protein resolved—important tool in the battle for food security

Nature (2022). DOI: 10.1038/s41586-022-05231-w” width=”800″ height=”368″/> Comparison of ZAR1, Sr35, ROQ1, RPP1 ligand binding sites. Ligand binding to LRR of CNLs (Zar1, Sr35) and LRR-CJID of TNLs (Roq1, RPP1) occurs in equivalent region in the ascending lateral side of the LRR domain (compare concave, convex, ascending and descending lateral sides defined on Zar1). . Credit: … Read more

The story of an unexpected protein structure

Structure of human NKR-P1 showing the unique dimerization interface. Panel (a) compares crystal structures of the NKR-P1 receptor binding domain dimers. Panel (b) shows a structural comparison of LLT1 (green) and NKR-P1 (cyan) dimers prepared by overlapping only one monomer from each dimer (middle). Although they both share a similar structure, their dimerization mode is … Read more

First structure of key COVID enzyme at human body temperature

Scientists used x-rays to decipher the three-dimensional structure of the main protease of the virus that causes COVID-19 at different temperatures. The background image shows the full structure at 240 Kelvin (-28°F, cyan stick figure) and 100 K (-280°F, dark blue). The red and green blobs represent differences in the structure at these distinct temperatures. … Read more

Artificial intelligence tools predict DNA’s regulatory role and 3D structure

Nature Genetics (2022). DOI: 10.1038/s41588-022-01102-2″ width=”800″ height=”530″/> Disease regulatory mutations are predicted to promoter, CTCF and tissue-specific enhancer sequence classes. Sequence class-level mutation effects of pathogenic noncoding HGMD mutations were plotted. A polar coordinate system was used, where the radial coordinate indicates the sequence class-level effects. Each dot represents a mutation and mutations inside the … Read more

Research team first to develop 3D structure of twinkle protein

Credit: AA Riccio, NIEHS Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein is involved in helping cells use energy our bodies convert from food. Prior to the development of this … Read more

AlphaFold predicts structure of almost every cataloged protein known to science

Credit: Karen Arnott/EMBL-EBI DeepMind and EMBL’s European Bioinformatics Institute (EMBL-EBI) have made AI-powered predictions of the three-dimensional structures of nearly all cataloged proteins known to science freely and openly available to the scientific community, via the AlphaFold Protein Structure Database. The two organizations hope the expanded database will continue to increase our understanding of biology, … Read more

Influence of nanoparticles, surrounding ions on formation of β-sheet structure in amyloid β proteins

Infrared (FT-IR) spectra and β-sheet ratio of Aβ peptides interacting with CeF3 NPs. The effect of CeF3 nanoparticles on amyloid beta protein structure is measured directly with FT-IR spectroscopy. The formation of secondary structure shows up as a feature in the IR spectrum. Credit: Masakazu Umezawa / Tokyo University of Science, License type: CC BY … Read more

Structure of cell growth regulator GATOR2 finally revealed

A 3D rendering of GATOR2. Credit: Kacper Rogala/Whitehead Institute An important function of our cells’ signaling pathways is to coordinate growth with environmental cues, such as the availability of nutrients in the cell’s environment. Cell growth plays an important role in normal cell function—for example, building muscle in response to exercise— and it also goes … Read more

Study provides new insights about the surface and structure of asteroid Bennu

An SwRI-led study found that the surface regolith of the asteroid Bennu is primarily loose rubble. Images taken before and after the touch-and-go sample collection indicate surface disturbances up to 15 inches away. Credit: NASA/Goddard/University of Arizona When NASA’s OSIRIS-REx spacecraft collected samples from asteroid Bennu’s surface in 2020, forces measured during the interaction provided … Read more

Team composition, structure, members’ gender influence ability to focus, work together

Credit: CC0 Public Domain The ability of team members to work together across a range of tasks, called collective intelligence (CI), varies significantly between teams. Research suggests that the level of collective attention (the quality and coordination of members’ focus) a team develops influences its level of CI. A new study examined what factors enhance … Read more