Scientists use modified silk proteins to create new nonstick surfaces

ChemBioChem (2022). DOI: 10.1002/cbic.202200429″ width=”800″ height=”435″/> Graphical abstract. Credit: ChemBioChem (2022). DOI: 10.1002/cbic.202200429 Researchers at Tufts University have developed a method to make silk-based materials that refuse to stick to water, or almost anything else containing water for that matter. In fact, the modified silk, which can be molded into forms like plastic, or coated … Read more

How proteins differ across species

Credit: Pixabay/CC0 Public Domain To better understand what drives biological diversity on Earth, scientists have historically looked at genetic differences between species. But this only provides part of the picture. The traits of a particular species are not simply the result of its genes but also the proteins those genes code for. Understanding the differences … Read more

Study on plant enzyme shows that proteins can change their structural arrangement with surprising ease

A comparison of rubisco assemblies from different species, illustrating a wide range of structures including a dimer, tetramer, hexamer, octamer, and hexadecamer (16 unit protein). Credit: Shih Lab/Berkeley Lab When you think of proteins—the enzymes, signaling molecules, and structural components in every living thing—you might think of single strands of amino acids, organized like beads … Read more

Enzyme, proteins work together to tidy up tail ends of DNA in dividing cells

Credit: Pixabay/CC0 Public Domain Researchers at the University of Wisconsin–Madison have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new insight into how a human cell preserves the integrity of its DNA through repeated cell division . DNA replication is essential for … Read more

Study probes role of BET proteins in coronavirus infection

Irene Chen (right) is the first author of a new study showing that BET proteins both enable and fight off COVID-19. She is shown here in the lab with Tongcui Ma (left). Credit: Michael Short / Gladstone Institutes A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and … Read more

Influence of nanoparticles, surrounding ions on formation of β-sheet structure in amyloid β proteins

Infrared (FT-IR) spectra and β-sheet ratio of Aβ peptides interacting with CeF3 NPs. The effect of CeF3 nanoparticles on amyloid beta protein structure is measured directly with FT-IR spectroscopy. The formation of secondary structure shows up as a feature in the IR spectrum. Credit: Masakazu Umezawa / Tokyo University of Science, License type: CC BY … Read more

Uncharted genetic territory offers insight into human-specific proteins

Uncharted territories in the human genome. Credit: Karen Arnott/EMBL-EBI When researchers working on the Human Genome Project completely mapped the genetic blueprint of humans in 2001, they were surprised to find only around 20,000 genes that produce proteins. Could it be that humans have only about twice as many genes as a common fly? Scientists … Read more

Researchers track protein binding, build synthetic proteins to study gene expression

Credit: Unsplash/CC0 Public Domain How does a nose remember that it’s a nose? Or an eye remember that it’s an eye? As scientists probe the question of how cells remember what kind of cells they are supposed to be, or their genetic lineage, it’s important to understand how cells express different genes without changing the … Read more

New method for developing Pichia pastoris yeast strains with high productivity of useful proteins

Communications Biology, 2022.” width=”800″ height=”242″/> Figure 1. Strategy for developing a Pichia pastoris strain for the production of useful proteins. Credit: Modified version of Ito et al, “A streamlined strain engineering workflow with genome-wide screening detects enhanced protein secretion in Komagataella phaffii,” Communications Biology2022. A collaboration including researchers from Kobe University, University of Tokyo and … Read more

New research transforms glucose transporter proteins to water-soluble form

Two angles of the crystalline structure GLUT1 (magenta) glucose transporter protein superposed with the AlphaFold2 computer-predicted water-soluble variant of the same protein (cyan) demonstrate that the crystalline protein and its water-soluble QTY variant share a remarkable structural similarity. Credit: Shuguang Zhang Laboratory, MIT All cell membranes in the human body have embedded proteins that serve … Read more