Structure of wheat immune protein resolved—important tool in the battle for food security

Nature (2022). DOI: 10.1038/s41586-022-05231-w” width=”800″ height=”368″/> Comparison of ZAR1, Sr35, ROQ1, RPP1 ligand binding sites. Ligand binding to LRR of CNLs (Zar1, Sr35) and LRR-CJID of TNLs (Roq1, RPP1) occurs in equivalent region in the ascending lateral side of the LRR domain (compare concave, convex, ascending and descending lateral sides defined on Zar1). . Credit: … Read more

Researchers identify more possible entry points for COVID spike protein

Journal of the American Chemical Society (2022). DOI: 10.1021/jacs.2c06806″ width=”800″ height=”363″/> The host cell and virus interface can be complex and involve many proteins, but µMap enables direct interrogation of functionally important interactions. Credit: Saori Suzuki et al, Journal of the American Chemical Society (2022). DOI: 10.1021/jacs.2c06806 One of the essential factors the COVID-19 virus … Read more

The story of an unexpected protein structure

Structure of human NKR-P1 showing the unique dimerization interface. Panel (a) compares crystal structures of the NKR-P1 receptor binding domain dimers. Panel (b) shows a structural comparison of LLT1 (green) and NKR-P1 (cyan) dimers prepared by overlapping only one monomer from each dimer (middle). Although they both share a similar structure, their dimerization mode is … Read more

Biologists glean insight into repetitive protein sequences

eLife (2022). DOI: 10.7554/eLife.77058″ width=”800″ height=”530″/> Using computational analysis, researchers have found that many repetitive sequences are shared across proteins and are similar in species from bacteria to humans. Credit: Byron Lee et al, eLife (2022). DOI: 10.7554/eLife.77058 About 70% of all human proteins include at least one sequence consisting of a single amino acid … Read more

Anti-insulin protein linked to longevity and reproduction in ants

Harpegnathos saltator worker ants. Credit: Hua Yan/NYU An insulin-suppressing protein may be the fountain of youth for ants and provides clues about aging in other species, according to a study led by New York University researchers. Published in Sciencethe study shows that queen ants exhibit high metabolism for reproduction without undergoing aging by generating an … Read more

SARS-CoV-2 genomic recombination is uncommon but disproportionately occurs in the spike protein region

Researchers found recombination of COVID-19, while uncommon, occurs most in the virus’s spike protein region. Credit: Centers for Disease Control and Protection An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the … Read more

Research team first to develop 3D structure of twinkle protein

Credit: AA Riccio, NIEHS Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein is involved in helping cells use energy our bodies convert from food. Prior to the development of this … Read more

AlphaFold predicts structure of almost every cataloged protein known to science

Credit: Karen Arnott/EMBL-EBI DeepMind and EMBL’s European Bioinformatics Institute (EMBL-EBI) have made AI-powered predictions of the three-dimensional structures of nearly all cataloged proteins known to science freely and openly available to the scientific community, via the AlphaFold Protein Structure Database. The two organizations hope the expanded database will continue to increase our understanding of biology, … Read more

What the mechanical forces behind protein folding can tell us about metastatic cancer

Ionel Popa, UWM professor of physics, demonstrates the magnetic tweezers he and his lab members built to measure the mechanical forces that act on proteins as they fold and refold. Proteins are large molecules that carry out the body’s functions required for good health. Credit: Elora Hennessey, UWM Talin is a protein that controls cellular … Read more

Protein parts must wiggle and jiggle to work right, new research suggests

Structural illustration of the HMWP2 enzyme domains, highlighting two interacting domains (shown in red and blue), the two remote binding sites (yellow stars), and the modification of one domain (green). Credit: Kenny Marincin and Dominique Frueh, Johns Hopkins Johns Hopkins Medicine scientists report they have probed the atomic structure of proteins to add to evidence … Read more