Technology that simulates complex molecular interactions could lead to better treatments for cancer and COVID-19

a A point-and-click interface enables the user to select the number of ligands (up to three) and valencies of the ligand(s) and receptor (up to trivalent) that compose the multivalent system. Based upon the chosen design, the user specifies the structure of each of the ligands by entering the applicable molecular weight (MW); the binding … Read more

Molecular atlas of an Australian dragon’s brain sheds new light on more than 300 million years of brain evolution

The Australian bearded dragon Pogona vitticeps. Credit: Max Planck Institute for Brain Research / G. Laurent These days, dragons are keeping “Game of Thrones” fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded … Read more

Analysis of molecular processes in living cells with sub-10 nm spatial resolution

The photoswitching rates of fluorescent dyes are as unique as a fingerprint and as readable as a barcode. Credit: Dr. Gerti Beliu Rudolf-Virchow-Zentrum, Universität Würzburg Researchers at the University of Würzburg have developed “photoswitching fingerprint analysis”—a unique technology that allows for the first time the analysis of molecular processes and the regulation of individual proteins … Read more

Researchers build the longest highly-conductive molecular nanowire

Top: the two-step oxidation of the bis(triarylamines) molecular series. Bottom: the geometry of the highest trimer (n=3) molecule in the molecular junction. Red and blue regions are artistic depictions on the coupling between the two edge states. Credit: Liang Li/Columbia University As our devices get smaller and smaller, the use of molecules as the main … Read more

Visible light triggers molecular machines to treat infections

The schematis show two variants of light-activated molecular machines developed at Rice University that drill into and destroy antibiotic-resistant bacteria. The machines could be useful to fight infectious skin diseases. Credit: Tour Research Group/Rice University Molecular machines that kill infectious bacteria have been taught to see their mission in a new light. The latest iteration … Read more

Two-step molecular process rewires nutrient transport in wild thale cress

Marie-Lan Nguyen/Wikimedia Commons, CC BY 2.5” width=”600″ height=”530″/> Thale cress (Arabidopsis thaliana), botanic school of the Jardin des Plantes of Paris, France. Credit: Marie-Lan Nguyen/Wikimedia Commons, CC BY 2.5 New research in plants that colonized the base of an active stratovolcano reveals that two simple molecular steps rewired nutrient transport, firing adaptation. An international team … Read more

‘Spring-loaded’ system pops phosphorus into molecular rings

Caption: MIT chemists discovered a way to incorporate phosphorus into three-membered ring compounds, using this “spring-loaded” molecule as the source of phosphorus. Credits: Courtesy of the researchers MIT chemists have devised a new chemical reaction that allows them to synthesize a phosphorus-containing ring, using a catalyst to add phosphorus to simple organic compounds called alkenes. … Read more