Structure of wheat immune protein resolved—important tool in the battle for food security

Nature (2022). DOI: 10.1038/s41586-022-05231-w” width=”800″ height=”368″/> Comparison of ZAR1, Sr35, ROQ1, RPP1 ligand binding sites. Ligand binding to LRR of CNLs (Zar1, Sr35) and LRR-CJID of TNLs (Roq1, RPP1) occurs in equivalent region in the ascending lateral side of the LRR domain (compare concave, convex, ascending and descending lateral sides defined on Zar1). . Credit: … Read more

Undergrad publications theory on immune dysfunction in space

Frontiers in Cell and Developmental Biology (2022). DOI: 10.3389/fcell.2022.997365″ width=”782″ height=”530″/> Credit: Rocky An, Frontiers in Cell and Developmental Biology (2022). DOI: 10.3389/fcell.2022.997365 It’s been known for decades that though astronauts’ immune systems became suppressed in space, leaving them vulnerable to disease, the exact mechanisms of immune dysfunction have remained a mystery. Now a Cornell … Read more

New method to more quickly and accurately find antigens that trigger specific immune cells

Credit: Pixabay/CC0 Public Domain A cell’s secrets can be divulged by its surface, decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe. Some of those protruding molecules are antigens that trigger the immune system to attack, but it can be difficult for scientists to identify those antigens, … Read more

A breakthrough for fast, efficient production of human immune cells

A) Schematic overview of chemically defined platform for producing multipotent hematopoietic progenitors and T cell progenitors from pluripotent stem cells. (B) Flow cytometry analysis of progenitor T cell output after transitioning cells from 7 days in each EHT coating condition into a common defined thymic niche for an additional 7 days. (C) Quantification of the … Read more

Detection of physical forces produced by bacterial infection can initiate the immune response

Colored electron microscopy image of a nascent plasma membrane ruffle enclosing a bacterium which invades an intestinal epithelial cell. Credit: Sample: Lalitha Tadala; Image acquisition: Ramón Cervantes-Rivera; Artistic rendering: Atin Sharma. MIMS, Umea University The immune system is under the constant challenge of specifically detecting dangerous microbes to remove them. Dr. Andrea Puhar and her … Read more

Scientists uncover novel aspects of HIV infection by monitoring sugars at the surface of individual immune cells

Gladstone researchers Tongcui Ma (left) and Nadia Roan (right) teamed up with collaborators to uncover new aspects of HIV infection by monitoring sugars at the surface of immune cells. Credit: Michael Short/Gladstone Institutes HIV researchers have long been trying to identify the specific cells that the virus prefers to infect and hide in. They know … Read more

A nanoparticle and inhibitor trigger the immune system, outsmarting brain cancer

Glioma cells. Credit: University of Michigan Rogel Cancer Center Scientists at the University of Michigan Rogel Cancer Center were optimism when they identified a small molecule that blocked a key pathway in brain tumors. But there was a problem: How to get the inhibitor through the bloodstream and into the brain to reach the tumor. … Read more

How immune cells enter tissue

Macrophages, a type of immune cell (purple), utilize the division of a tissue cell (green) to invade tissues. Credit: © Maria Akhmanova/ISTA To get to the places where they are needed, immune cells not only squeeze through tiny pores. They even overcome wall-like barriers of tightly packed cells. Researchers at the Institute of Science and … Read more