Fish can help in the search for multiple sclerosis drugs

Zebrafish and humans both have a GPR17 receptor. In the study, the fish receptor was replaced by its human counterpart. This makes it more likely to find pharmacologically active substances. Credit: AG Kostenis-Gomeza / University of Bonn The zebrafish should be known to many aquarium enthusiasts, mainly because of its striking pigmentation. However, the characteristic … Read more

COVID-19 drugs persist in wastewater, may pose risk to aquatic organisms

Treated wastewater efluent is sprayed at Penn State’s beneficial reuse site, the “Living Filter.” This diverts the wastewater from Spring Creek and allows the soil to act as a natural filter for any chemical residuals that remain in the wastewater. Credit: Heather Preisendanz, Penn State Certain drugs used to treat COVID-19 patients—including remdesivir, dexamethasone and … Read more

World’s tiniest plumbing could one day funnel drugs to individual human cells

Tubes, visible in light green, are roughly seven nanometers in diameter — about two million times smaller than an ant — and several microns long, or about the length of a dust particle. Credit: Johns Hopkins University Working on microscopic pipes only a millionth as wide as a single strand of human hair, Johns Hopkins … Read more

Long-term mystery on muscle mechanisms may be solved, and may lead to better drugs

Nature Communications (2022). DOI: 10.1038/s41467-022-32110-9″ width=”800″ height=”530″/> Modeling of Pi-release of striated muscle (cardiac) myosin II. a Schematic illustration of Pi-release from myosin subfragment 1: with binding of ATP (1), Pi-binding to the active site (2) Pi-binding to the secondary site (3) release via the back door and finally weak electrostatic binding to surface sites … Read more

First cryo-EM structures of angiotensin-converting enzyme pave the way for better drugs to treat heart disease

Cryo-EM structures of the hourglass-shaped ACE monomer (one protein copy; left) and dimer (two interacting protein copies; middle). A flexible loop (yellow; protein center) acts as a hub for communication between different areas of the protein. Dimerization is like a ‘kiss of death’ since it triggers conformational changes in the protein core that likely inactivate … Read more