New study allows scientists to test therapies for rare neurodegenerative disease affecting young children

In this image of a human STEM cell derived neuron, the Trk-fused gene protein (TFG) is shown in green and the Golgi Apparatus, the organelle which helps package proteins for transport to the rest of the body, is shown in red. Credit: University of Wisconsin-Madison For the first time, scientists will be able to test … Read more

WHO raises alarm on disease in flood-hit areas of Pakistan

Displaced families, who fled their flood-hit homes, jostle to get relief aid distributed by soldiers of Pakistan rangers, in Dera Allahyar, in Jaffarabad, a district of southwestern Balochistan province, Saturday, Sept. 17, 2022. The floods affected over 33 million people and displaced over half a million people who are still living in tents and make-shift … Read more

Can wild potato relatives help tame zebra chip disease?

Kranthi Mandadi, Ph.D, a Texas A&M AgriLife Research scientist at the Texas A&M AgriLife Research and Extension Center in Weslaco, was the primary investigator for the new zebra chip-related study. Credit: Texas A&M AgriLife photo A new study led by Texas A&M AgriLife researchers has revealed some resistance to zebra chip disease among certain wild … Read more

Nanorattles shake up new possibilities for disease detection

Journal of Raman Spectroscopy (2022). DOI: 10.1002/jrs.6447″ width=”800″ height=”530″/> (a) Steps in nanorattle synthesis: 20 nm Au spheres, growth of Ag cube, galvanic replacement resulting in Au@Ag cage, dye loading, final Au coating, and DNA probe functionalization. (b) TEM of nanorattle. (c) Hybridization scheme of nanorattle and magnetic bead hybridization assay. (d) Nanorattle assay steps: … Read more

Liquid-interface assisted SERS could see earlier detection of Alzheimer’s disease

Figure 1. Schematic of laser fabrication system for microfluidic SERS chips. Credit: Compuscript Ltd A new publication from Opto-Electronic Advances discusses label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip. Surface-enhanced Raman scattering (SERS) has attracted attention in biotechnology. It is due to its high sensitivity to localized surface … Read more

Researchers identify a potential path against inherited neurological disease

Researchers at the Icahn School of Medicine at Mount Sinai and NCATS identified compounds that reversed the effects of several neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice. LSDs are characterized by genetic defects that prevent the cell’s lysosomes from breaking down and recycling fats, sugars and proteins, which can accumulate … Read more

Researchers find spaceflight may be associated with DNA mutations, increased risk of heart disease and cancer

a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood mononuclear cells isolated from 14 astronauts who flew short space Shuttle missions lasting a median of 12 days between 1998–2001. Created with BioRender.com. b) Number of somatic nonsynonymous single nucleotide variants (SNVs) in CHIP-driver genes harbored per … Read more

Slugs, snails are not alone in causing rat lungworm disease in humans

Platydemus manokwari, an introduced flatworm present in Hawaii’i, which can act as a paratenic host of the rat lungworm parasite and that has been implicated in causing rat lungworm disease in Okinawa. Credit: Shinji Sugiura. A review of decades of research revealed more than a dozen kinds of animals in addition to slugs and snails … Read more

New clues to how plants retain healthy genomes, avoid mitochondrial disease

MSH1 repairs organelle DNA. The MSH1 protein slides along a DNA strand until it detects mutations. Then MSH1 cuts both strands of DNA. The DNA repair machinery in the cell uses homologous DNA (DNA of the same sequence) as a template to fix the mutation. B) MSH1 increases sorting of organelle DNA. A population of … Read more

Famine and disease drove the evolution of lactose tolerance in Europe

Credit: Pixabay/CC0 Public Domain Prehistoric people in Europe were consuming milk thousands of years before humans evolved the genetic trait allowing us to digest the milk sugar lactose as adults, finds a new study. The research, published in Naturemapped pre-historic patterns of milk use over the last 9,000 years, offering new insights into milk consumption … Read more