Nanorattles shake up new possibilities for disease detection

Journal of Raman Spectroscopy (2022). DOI: 10.1002/jrs.6447″ width=”800″ height=”530″/> (a) Steps in nanorattle synthesis: 20 nm Au spheres, growth of Ag cube, galvanic replacement resulting in Au@Ag cage, dye loading, final Au coating, and DNA probe functionalization. (b) TEM of nanorattle. (c) Hybridization scheme of nanorattle and magnetic bead hybridization assay. (d) Nanorattle assay steps: … Read more

Liquid-interface assisted SERS could see earlier detection of Alzheimer’s disease

Figure 1. Schematic of laser fabrication system for microfluidic SERS chips. Credit: Compuscript Ltd A new publication from Opto-Electronic Advances discusses label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip. Surface-enhanced Raman scattering (SERS) has attracted attention in biotechnology. It is due to its high sensitivity to localized surface … Read more

Revealed missing step in lipid formation could enable detection of past climates

A team from Penn State and the University of Illinois Urbana-Champaign has determined the missing step in the formation of a molecule called GDGT, which is a promising candidate for use as an indicator of past climate. The team determined the X-ray crystal structure of an enzyme that facilitates this process called GDGT/MAS—shown here bound … Read more

Detection of physical forces produced by bacterial infection can initiate the immune response

Colored electron microscopy image of a nascent plasma membrane ruffle enclosing a bacterium which invades an intestinal epithelial cell. Credit: Sample: Lalitha Tadala; Image acquisition: Ramón Cervantes-Rivera; Artistic rendering: Atin Sharma. MIMS, Umea University The immune system is under the constant challenge of specifically detecting dangerous microbes to remove them. Dr. Andrea Puhar and her … Read more